Table 3.
Effect of curcumin-loaded liposomes and nanoparticles on hepatic toxicity in CCl4-induced hepatic damage
| Groups | Alkaline phosphatase (KA units) | Serum AST (IU/L) | Serum ALT (IU/L) |
|---|---|---|---|
| Normal | 34.5±1.9 | 112.5±6.3 | 37.8±3.6 |
| CCl4 treated (A) | 89.8±2.3** | 247.1±7.9** | 116.7±3.5** |
| A + empty liposome treated | 79.8±4.3 | 242.83±7.5 | 111.5±4.3 |
| A + empty nanocapsule treated | 78.2±3.6 | 239.3±8.5 | 109.2±2.0 |
| A + free Cur treated | 67.9±2.01## | 205.8±5.8## | 87.5±4.6# |
| A + liposomal Cur treated | 59.9±2.2## | 176.1±7.9## | 59.5±7.2## |
| A + nanocapsulated Cur treated | 48.3±1.2## | 131.4±7.5## | 48.5±3.7## |
Notes: Results of each group were expressed as mean ± SD of five animals. CCl4-treated controls were compared with normal animals (**P<0.001) and other experimental groups showed significant difference (##P<0.001 and #P<0.01) from the CCl4-treated control group (A).
Abbreviations: AST, aspartate transaminase; ALT, alanine transaminase; SD, standard deviation.