Table 2.
LC-MS/MS data: Protein MW isoforms significantly associated with NAB
| UniProt ID | Protein name | 1D-GE fraction | Protein level data (roll up method indicated; i.e., mean or median) |
Tests with P < .05 (n) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean for all peptides mapping to protein |
Median over all peptides mapping to protein |
||||||||||||||||||
| Logistic regression |
Mann-Whitney U test |
Linear regression |
Spearman's rank correlation |
Logistic regression |
Mann-Whitney U test |
Linear regression |
Spearman's rank correlation |
||||||||||||
| β | P value | Median difference | P value | β | P value | ρ | P value | β | P value | Median difference | P value | β | P value | ρ | P value | ||||
| P0C0L4 | Complement C4a | 7 | −0.656 | .038∗ | −0.235 | .027∗ | −0.162 | .019∗ | −0.302 | .007∗ | −0.592 | .049∗ | −0.224 | .037∗ | −0.143 | .042∗ | −0.229 | .044∗ | 8 |
| P00738 | Haptoglobin | 8 | −0.932 | .015∗ | −0.331 | .011∗ | −0.170 | .026∗ | −0.248 | .047∗ | −1.048 | .018∗ | −0.190 | .030∗ | −0.157 | .043∗ | −0.226 | .070 | 7 |
| P02647 | Apolipoprotein A-I | 10 | −0.877 | .014∗ | −0.173 | .070 | −0.211 | .013 | −0.204 | .136 | −0.872 | .025∗ | −0.087 | .087 | −0.183 | .035∗ | −0.266 | .049∗ | 5 |
| O14791 | Apolipoprotein L-1 | 5 | 0.829 | .048∗ | 0.731 | .004∗ | 0.165 | .035∗ | 0.308 | .014∗ | 0.578 | .091 | 0.795 | .007∗ | 0.120 | .145 | 0.238 | .061 | 5 |
| P00738 | Haptoglobin | 5 | −0.728 | .023∗ | −0.521 | .017∗ | −0.198 | .005∗ | −0.280 | .013∗ | −0.446 | .109 | −0.367 | .134 | −0.149 | .041∗ | −0.181 | .112 | 5 |
| Q03591 | FHR-1 | 8 | 1.667 | .120 | 0.313 | .008∗ | 0.155 | .178 | 0.483 | .007∗ | 1.414 | .187 | 0.186 | .019∗ | 0.144 | .217 | 0.444 | .014∗ | 4 |
| P25311 | Zinc-α2-glycoprotein | 7 | 0.140 | .681 | 0.327 | .043∗ | 0.076 | .461 | 0.327 | .021∗ | 0.140 | .681 | 0.327 | .043∗ | 0.076 | .461 | 0.327 | .021∗ | 4 |
| O43866 | CD5 molecule like | 5 | −0.929 | .110 | −0.398 | .013∗ | −0.140 | .088 | −0.288 | .028∗ | −0.596 | .080 | −0.307 | .015∗ | −0.165 | .042∗ | −0.235 | .076 | 4 |
| P04196 | Histidine rich glycoprotein | 5 | −0.996 | .031∗ | −0.093 | .150 | −0.228 | .011∗ | −0.238 | .096 | −0.996 | .031∗ | −0.093 | .150 | −0.228 | .011∗ | −0.238 | .096 | 4 |
| P02747 | C1q subcomponent subunit | 2 | −0.746 | .043∗ | −0.460 | .095 | −0.201 | .024∗ | −0.210 | .165 | −0.746 | .043∗ | −0.460 | .095 | −0.201 | .024∗ | −0.210 | .165 | 4 |
| P00450 | Ceruloplasmin | 6 | −2.088 | .032∗ | −0.222 | .019∗ | −0.105 | .169 | −0.154 | .247 | −2.088 | .032∗ | −0.222 | .019∗ | −0.105 | .169 | −0.154 | .247 | 4 |
| P04196 | Histidine rich glycoprotein | 3 | 1.205 | .039∗ | 0.334 | .034∗ | 0.120 | .169 | 0.106 | .449 | 1.149 | .024∗ | 0.611 | .030∗ | 0.114 | .199 | 0.084 | .548 | 4 |
| P00751 | Complement factor B | 1 | 0.341 | .419 | 0.065 | .657 | 0.164 | .081 | 0.310 | .038∗ | 1.239 | .371 | 0.058 | .188 | 0.189 | .042∗ | 0.363 | .014∗ | 3 |
| P04003 | C4b-binding protein α chain | 4 | −0.405 | .189 | −0.108 | .174 | −0.127 | .076 | −0.248 | .035 | −0.466 | .106 | −0.473 | .038∗ | −0.105 | .154 | −0.275 | .018∗ | 3 |
| P02647 | Apolipoprotein A-I | 6 | −0.487 | .080 | −0.074 | .310 | −0.157 | .023∗ | −0.189 | .098 | −0.403 | .137 | −0.156 | .109 | −0.143 | .038∗ | −0.236 | .038∗ | 3 |
| P02679 | FGG | 6 | 0.108 | .789 | −0.038 | .081 | 0.044 | .613 | −0.331 | .021∗ | −0.671 | .085 | −0.206 | .164 | −0.191 | .021∗ | −0.298 | .039∗ | 3 |
| Q92620 | DEAH box protein 38 | 2 | −0.383 | .351 | 0.046 | .044∗ | −0.095 | .207 | 0.223 | .067 | −0.380 | .351 | 0.046 | .031∗ | −0.095 | .208 | 0.243 | .046∗ | 3 |
| Q06033 | ITI heavy chain H3 | 2 | 1.525 | .027∗ | 0.297 | .099 | 0.148 | .144 | 0.170 | .265 | 1.267 | .019∗ | 0.422 | .013∗ | 0.187 | .061 | 0.225 | .137 | 3 |
| P06727 | Apolipoprotein A-IV | 6 | −1.837 | .206 | −0.100 | .087 | −0.144 | .115 | −0.389 | .010∗ | −1.432 | .271 | −0.093 | .107 | −0.139 | .128 | −0.387 | .010∗ | 2 |
| O43866 | CD5 molecule like | 6 | 0.556 | .275 | 0.277 | .147 | 0.077 | .400 | 0.347 | .022∗ | 0.260 | .484 | 0.623 | .201 | 0.090 | .313 | 0.369 | .015∗ | 2 |
| P08603 | Complement factor H | 6 | 0.031 | .917 | 0.147 | .409 | −0.001 | .989 | 0.128 | .299 | 0.190 | .490 | 0.243 | .041∗ | −0.001 | .987 | 0.286 | .018∗ | 2 |
| P01023 | α2m | 3 | 0.046 | .853 | 0.331 | .130 | 0.048 | .497 | 0.290 | .010∗ | 0.034 | .893 | 0.351 | .223 | 0.042 | .559 | 0.254 | .025∗ | 2 |
| P07357 | Complement C8 α chain | 5 | −0.303 | .346 | −0.294 | .111 | −0.105 | .229 | −0.197 | .137 | −0.539 | .104 | −0.474 | .032∗ | −0.153 | .073 | −0.261 | .048∗ | 2 |
| P00739 | Haptoglobin-related protein | 5 | 0.960 | .076 | 0.190 | .072 | 0.209 | .016∗ | 0.232 | .104 | 0.960 | .076 | 0.190 | .072 | 0.209 | .016∗ | 0.232 | .104 | 2 |
| P08519 | Apolipoprotein(a) | 1 | 0.929 | .062 | 0.315 | .030∗ | 0.115 | .212 | 0.237 | .105 | 0.869 | .064 | 0.222 | .045∗ | 0.111 | .226 | 0.221 | .131 | 2 |
| P04003 | C4b-binding protein α chain | 7 | −0.602 | .064 | −0.198 | .238 | −0.153 | .028∗ | −0.156 | .173 | −0.648 | .052 | −0.199 | .151 | −0.158 | .023∗ | −0.150 | .189 | 2 |
| P19823 | ITI heavy chain H2 | 4 | −0.762 | .067 | −0.294 | .026∗ | −0.159 | .061 | −0.267 | .039∗ | −0.510 | .105 | −0.412 | .125 | −0.134 | .112 | −0.158 | .227 | 2 |
| P01024 | Complement C3 | 6 | −0.374 | .171 | 0.034 | .783 | −0.148 | .035∗ | −0.107 | .351 | −0.445 | .116 | −0.115 | .475 | −0.156 | .025∗ | −0.119 | .300 | 2 |
| Q92620 | DEAH box protein 38 | 5 | 0.449 | .199 | 0.123 | .576 | 0.197 | .038∗ | 0.144 | .318 | 0.449 | .199 | 0.123 | .576 | 0.197 | .038∗ | 0.144 | .318 | 2 |
| Q14624 | ITI heavy chain H4 | 1 | 1.244 | .041∗ | 0.187 | .118 | 0.251 | .013∗ | 0.222 | .142 | 0.651 | .220 | 0.127 | .281 | 0.152 | .139 | 0.136 | .373 | 2 |
| P00747 | Plasminogen | 1 | 0.901 | .026∗ | 0.610 | .078 | 0.151 | .112 | 0.154 | .295 | 0.786 | .049∗ | 0.409 | .102 | 0.128 | .182 | 0.119 | .420 | 2 |
| P06396 | Gelsolin | 5 | 1.018 | .251 | 0.174 | .033∗ | 0.095 | .275 | 0.171 | .198 | 1.149 | .202 | 0.151 | .042∗ | 0.095 | .275 | 0.088 | .509 | 2 |
| P01023 | α2m | 9 | −0.749 | .035∗ | −0.246 | .112 | −0.196 | .037∗ | −0.092 | .482 | −0.555 | .078 | −0.165 | .230 | −0.139 | .113 | −0.044 | .737 | 2 |
| O75636 | Ficolin-3 | 6 | −0.372 | .249 | 0.043 | .629 | −0.152 | .044∗ | 0.034 | .798 | −0.372 | .249 | 0.043 | .629 | −0.152 | .044∗ | 0.034 | .798 | 2 |
| P19827 | ITI heavy chain H4 | 8 | −0.396 | .253 | −0.252 | .301 | −0.155 | .115 | −0.265 | .069 | −0.337 | .373 | −0.196 | .282 | −0.164 | .113 | −0.313 | .030∗ | 1 |
| P01023 | α2m | 2 | −0.044 | .861 | −0.190 | .823 | 0.000 | .996 | 0.013 | .912 | 0.108 | .659 | 0.259 | .171 | 0.048 | .495 | 0.237 | .037 | 1 |
| P02790 | Hemopexin | 5 | 0.255 | .341 | 0.018 | .368 | 0.080 | .252 | 0.152 | .184 | 0.424 | .158 | 0.164 | .123 | 0.105 | .134 | 0.228 | .045∗ | 1 |
| P01023 | α2m | 1 | 0.325 | .196 | 0.198 | .133 | 0.057 | .420 | 0.118 | .303 | 0.340 | .181 | 0.469 | .046∗ | 0.063 | .380 | 0.184 | .107 | 1 |
| P13671 | Complement C6 | 2 | −0.454 | .132 | −0.338 | .064 | −0.089 | .288 | −0.167 | .190 | −0.430 | .145 | −0.662 | .048∗ | −0.085 | .310 | −0.203 | .110 | 1 |
| P02675 | Fibrinogen β chain | 6 | −0.441 | .241 | 0.042 | .869 | −0.113 | .117 | −0.082 | .504 | −0.539 | .090 | −0.213 | .341 | −0.172 | .016∗ | −0.188 | .125 | 1 |
| P02790 | Hemopexin | 6 | 0.587 | .049∗ | 0.216 | .053 | 0.090 | .203 | 0.230 | .059 | 0.429 | .147 | 0.234 | .082 | 0.041 | .562 | 0.166 | .176 | 1 |
| P01024 | Complement C3 | 8 | −0.569 | .058 | −0.480 | .030∗ | −0.129 | .101 | −0.166 | .161 | −0.422 | .132 | −0.401 | .081 | −0.091 | .249 | −0.135 | .255 | 1 |
| P02787 | Serotransferrin | 1 | 0.123 | .658 | 0.205 | .170 | 0.046 | .544 | 0.093 | .450 | 0.249 | .372 | 0.352 | .040∗ | 0.068 | .370 | 0.133 | .281 | 1 |
| P02647 | Apolipoprotein A-I | 5 | −0.458 | .221 | −0.293 | .126 | −0.101 | .229 | −0.263 | .046∗ | −0.237 | .484 | −0.099 | .333 | −0.026 | .762 | −0.129 | .335 | 1 |
| P0C0L4 | Complement C4a | 1 | 0.735 | .117 | 0.058 | .937 | 0.241 | .009∗ | 0.160 | .293 | 0.156 | .631 | −0.004 | .847 | 0.064 | .513 | 0.124 | .419 | 1 |
| P02647 | Apolipoprotein A-I | 9 | −0.599 | .039∗ | −0.061 | .255 | −0.134 | .060 | −0.033 | .780 | −0.414 | .134 | 0.036 | .812 | −0.090 | .211 | 0.067 | .566 | 1 |
| P00450 | Ceruloplasmin | 2 | 0.543 | .136 | −0.097 | .638 | 0.167 | .029∗ | 0.000 | .998 | 0.177 | .524 | 0.038 | .946 | 0.082 | .302 | 0.058 | .639 | 1 |
| P00734 | Prothrombin | 6 | 1.356 | .402 | 0.004 | .409 | 0.190 | .027∗ | 0.208 | .135 | −0.053 | .879 | −0.001 | .908 | −0.002 | .983 | 0.056 | .689 | 1 |
| P10909 | Clusterin | 6 | −0.480 | .134 | 0.036 | .422 | −0.159 | .037∗ | −0.102 | .408 | −0.434 | .179 | −0.150 | .646 | −0.140 | .068 | −0.033 | .789 | 1 |
| P02671 | Fibrinogen α chain | 4 | −0.698 | .122 | −0.175 | .107 | −0.142 | .052 | −0.284 | .012∗ | −0.054 | .835 | 0.065 | .700 | −0.054 | .472 | −0.028 | .809 | 1 |
| P04196 | Histidine rich glycoprotein | 6 | −0.459 | .343 | 0.005 | .447 | −0.185 | .049∗ | −0.194 | .214 | −0.315 | .485 | 0.251 | .895 | −0.163 | .083 | −0.021 | .895 | 1 |
Abbreviations: 1D-GE, one-dimensional gel electrophoresis; α2m, α2-macroglobulin; FGG, fibrinogen γ-chain; FHR-1, factor H-related protein 1; ID, identification; ITI, inter-α-trypsin inhibitor; LC-MS/MS, liquid chromatography tandem mass spectrometry; UniProt, Universal Protein Resource.
NOTE. All multiple testing corrected q values were >0.75; for regression analysis, age, gender, and presence of apolipoprotein E ε4 were used as covariates.
∗Statistically significant.