Table 3.

Technical replication of plasma protein candidates discovered by LC-MS/MS

UniProt ID	Protein name	Outliers excluded (n)	Logistic regression with SUVR >1.3			Linear regression with SUVR
β	P value	q value	β	P value	q value
P01023	α2m	10	1	8.9 × 10−3	0.076	0.2	7.9 × 10−3	0.068
Q03591	FHR-1	11	−1	4.6 × 10−3	0.076	−0.22	5.5 × 10−3	0.068
P02679	FGG	0	−0.7	.041	0.23	−0.2	.014	0.081
P08519	Apolipoprotein(a)	21	0.48	.13	0.34	0.18	.042	0.18
P06396	Gelsolin	2	−0.48	.11	0.34	−0.14	.068	0.19
P00738	Haptoglobin	2	−0.38	.18	0.39	−0.13	.089	0.19
P04196	Histidine rich glycoprotein	2	0.48	.14	0.34	0.14	.081	0.19
P06727	Apolipoprotein A-IV	2	−0.63	.083	0.34	−0.17	.067	0.19
P01024	Complement C3	0	−0.61	.25	0.47	−0.21	.13	0.25
P0C0L4	Complement C4a	0	−0.55	.51	0.66	−0.27	.22	0.38
P10909	Clusterin	0	−0.27	.36	0.51	−0.091	.27	0.41
P02647	Apolipoprotein A-I	0	0.34	.29	0.47	0.088	.32	0.46
P02671	Fibrinogen α chain	6	−0.28	.3	0.47	−0.064	.39	0.52
P02787	Serotransferrin	1	−0.013	.96	0.96	−0.041	.6	0.73
O14791	Apolipoprotein L-1	0	−0.09	.74	0.89	−0.026	.73	0.77
P08603	Complement factor H	3	0.066	.8	0.89	0.027	.7	0.77
P00751	Complement factor B	2	0.053	.84	0.89	0.018	.81	0.81

Abbreviations: 1D-GE, one-dimensional gel electrophoresis; α2m, α2-macroglobulin; FGG, fibrinogen γ-chain; FHR-1, factor H-related protein 1; ID, identification; ITI, inter-α-trypsin inhibitor; LC-MS/MS, liquid chromatography tandem mass spectrometry; UniProt, Universal Protein Resource.