Table 4.
Independent replication of plasma protein candidates discovered by LC-MS/MS and technically replicated
| UniProt ID | Protein name | Logistic regression to visual read |
Logistic regression to SUVR >1.3 |
Linear regression to SUVR |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | P value | q value | β | P value | q value | β | P value | q value | ||
| P01023 | α2m | −0.013 | .96 | 0.96 | 0.27 | .29 | 0.44 | 0.075 | .22 | 0.33 |
| P02679 | FGG | −1.0 | 2.0 × 10−3 | 5.9 × 10−3 | −0.74 | .017 | 0.051 | −0.21 | 4.1 × 10−4 | 1.2 × 10−3 |
| Q03591 | FHR-1 | −0.066 | .79 | 0.96 | 0.011 | .97 | 0.97 | 1.5 × 10−3 | .98 | 0.98 |
Abbreviations: α2m, α2-macroglobulin; FGG, fibrinogen γ-chain; FHR-1, factor H-related protein 1; ID, identification; LC-MS/MS, liquid chromatography-tandem mass spectrometry; SUVR, standardized uptake value ratio; UniProt, Universal Protein Resource.
NOTE. Only one outlier (>3 standard deviations from mean) was excluded, which was detected for FGG; for regression analysis, age, gender, presence of apolipoprotein E ε4, enzyme-linked immunosorbent assay plate, and scanner type were used as covariates.