Figure 2.

Mean ± SEM concentrations of (A) blood glucose and (B) plasma insulin in the basal (stippled columns) and hyperinsulinaemic (Stripped columns) periods of the hyperinsulinaemic-euglycaemic clamp, rates of glucose infusion (GIR), appearance (R_a) and disappearance (R_d) measured directly (C) or derived indirectly as differences in rates (D) from tritiated glucose infusion and the HEC protocol (whole body and hepatic insulin sensitivity and endogenous glucose production, EGP) in non-pregnant (NP) females (n=7, white columns) and pregnant dams at D16 (n=5, grey columns) and D19 (n=6, black columns). In (B) *significant difference in concentration from the basal period (p<0.01, paired t-test) while, within each period of the clamp, values with different superscripts are significantly different from each other (p<0.05, one-way ANOVA). In (C) and (D) rates with different superscripts are significantly different from each other (p<0.05, one-way ANOVA). In (D) * significant difference between the values in the two states of the clamp (P<0.02, paired t-test).