WS6 does not adversely affect human islet viability. Analysis of human islets exposed to WS6 1.0 μM or DMSO (control) for 96 hours.
A. Viability of human islet cells as assayed by flow cytometry Live/Dead assay. Gating strategy (left) and quantification of viable cells (right, n = 3 from 3 different donors, p = NS.) B. Analysis of apoptosis by immunofluorescent TUNEL assay. Left - Arrows indicate TUNEL+ cells (Green = TUNEL staining, Blue = DAPI). Right – Quantification of TUNEL+ cells per islet (n = 3 from 3 different donors, p = NS). (Bars indicate mean ± SEM. Scale bar = 50 μm)