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. Author manuscript; available in PMC: 2016 Nov 5.
Published in final edited form as: Nature. 2016 May 5;533(7601):100–104. doi: 10.1038/nature17949

Figure 2. Functional properties of T cells in EVD patients.

Figure 2

a, Frequencies of CD8 T cells co-expressing the indicated markers. b, Plots of two surviving and two fatal EVD patients depicting CD8 T cell populations co-expressing the indicated markers. Overlays indicate activation status of CTLA-4+ CD8 T cells (red). Total CD8 T cells are represented by black contours. c, CD4 T cells co-expressing the indicated markers. d, Plots of two surviving and two fatal patients depicting CD4 T cell populations co-expressing the indicated markers. Overlays indicate activation status of CTLA-4+ CD4 T cells (red). Total CD4 T cells are represented by black contours. e, Correlation between frequency of CD8 T cells (upper graph) and CD4 T cells (lower graph) expressing CTLA-4 and Ct values. f, Correlation between the frequency of CD8 T cells (upper graph) and CD4 T cells (lower graph) positive for PD-1 and Ct values. Statistics was performed by Mann-Whitney test. ns, not significant; * p≤0.05; ** p≤0.01.