Extended Data Figure 2. Epidemiological data of patients tested by EMLab unit in Coyah.

a and b, Demographic data of the Coyah EVD patient cohort. Adults were ≥ 18 years of age and pediatric patients were < 18 years of age. The median age of the 157 patients in the study was 26 years (interquartile range (IQR) 20–38 years). Percentages of males and females were comparable within all groups, with adults accounting for 79% of patients. c, Box and whisker plots depicting statistical association between Ct values and outcome. The case-fatality ratio (CFR) was 51.6%. Fatalities and survivors were compared via non-parametric Mann-Whitney test; *** p<0.001. d, Correlation between Ct value and age of the patients. The Ct value did not correlate with age. However, survivors clustered in a group characterized by Ct value higher than 18 and by age less than 40 years (cluster encircled in blue). Statistical significance was tested by non-parametric Spearman correlation analysis. e, Ct values correlated negatively with symptom scoring, so that low Ct values were associated with severe disease symptoms. Symptom score was calculated as the summation of individual symptoms (bleeding, liver dysfunction, respiratory distress, kidney failure, neurological symptoms and anorexia) from ‘0’ (no symptoms) to ‘6’ (all symptoms present). In the box and whisker plot the ends of the whiskers represent the 10th and 90th percentile, respectively. Statistical analysis was performed by non-parametric Mann-Whitney test. The level of significance is indicated as follows: ns, not significant; * p≤0.05; *** p≤0.0001.