Table 1.
Characteristics of the study population (n = 1967a)
| Continuous variables | N | Mean | Standard deviation |
|---|---|---|---|
| Age (years) | 1967 | 64.8 | 14.1 |
| Weight (kg) | 1886 | 79.5 | 19.0 |
| Systolic blood pressure (mmHg) | 1962 | 143.8 | 22.0 |
| Diastolic blood pressure (mmHg) | 1962 | 81.8 | 13.0 |
| Total cholesterol (mmol/L) | 1828 | 4.72 | 1.21 |
| Triglycerides (mmol/L) | 1828 | 1.80 | 1.21 |
| HDL cholesterol (mmol/L) | 1822 | 1.34 | 0.43 |
| LDL cholesterol (mmol/L) | 1775 | 2.59 | 1.02 |
| Serum creatinine (mmol/L) | 1967 | 83.9 | 25.7 |
| eGFR (mL/min per 1.73 m2) | 1967 | 77.4 | 20.8 |
| Serum B12 (pmol/L) | 1671 | 332.1 | 180.1 |
| Plasma total homocysteine (µmol/L) | 1967 | 11.1 | 4.49 |
| Smoking (pack years) | 1950 | 15.2 | 20.5 |
| Stenosis % total (right and left ICA) | 1965 | 75.9 | 28.5 |
| TPA (mm2) | 1967 | 123 | 133 |
| Categorical variables | N | % | |
| Male | 1967 | 995 | 50.6 |
| Diabetic | 1957 | 368 | 18.8 |
| Smoking status | 1967 | ||
| Never | 766 | 38.9 | |
| Quit | 830 | 42.2 | |
| Still smoking | 371 | 18.9 |
We excluded patients with creatinine of >300 or of <15 mmol/L and patients with homocysteine of >40 μmol/L.
If B12 was >1000 pmol/L, we replaced the value by 1000. eGFR was derived from CKD/EPI formulae; ICA, internal carotid artery.
aNumber of patients with variables used in the regression models.