Table 2.
Association of eGFR versus homocysteine with vascular outcomes
| Beta (SE) | P-value | |
|---|---|---|
| A. Outcome = TPA | ||
| Unadjusted regression (N = 1967) | ||
| Model 1 (R2 = 0.17) | ||
| eGFR | −0.03 (0.002) | <0.0001 |
| Model 2 (R2 = 0.08) | ||
| tHcy | 1.24 (0.10) | <0.0001 |
| Model 3 (R2 = 0.18) | ||
| eGFR | −0.03 (0.002) | <0.0001 |
| tHcy | 0.51 (0.10) | <0.0001 |
| Adjusted regression (N = 1690) | ||
| Model 1 (R2 = 0.44) | ||
| eGFR | −0.005 (0.002) | 0.006 |
| Model 2 (R2 = 0.44) | ||
| tHcy | 0.26 (0.09) | 0.003 |
| Model 3 (R2 = 0.44) | ||
| eGFR | −0.004 (0.002) | 0.06 |
| tHcy | 0.20 (0.09) | 0.03 |
| B. Outcome = stenosis | ||
| Unadjusted regression (N = 1965) | ||
| Model 1 (R2 = 0.02) | ||
| eGFR | −0.17 (0.03) | <0.0001 |
| Model 2 (R2 = 0.01) | ||
| tHcy | 5.99 (1.67) | 0.0003 |
| Model 3 (R2 = 0.02) | ||
| eGFR | −0.15 (0.03) | <0.0001 |
| tHcy | 2.38 (1.86) | 0.20 |
| Adjusted regression (N = 1688) | ||
| Model 1 (R2 = 0.06) | ||
| eGFR | −0.08 (0.04) | 0.08 |
| Model 2 (R2 = 0.06) | ||
| tHcy | 3.61 (1.88) | 0.06 |
| Model 3 (R2 = 0.06) | ||
| eGFR | −0.05 (0.04) | 0.23 |
| tHcy | 2.80 (2.00) | 0.16 |
Carotid plaque burden is measured by TPA and total stenosis is measured by the sum of % stenosis in the right and left internal carotid arteries. TPA and tHcy, not eGFR and stenosis, are in log scale due to skewness. Model 1 has eGFR in the model, Model 2 has tHcy in the model and Model 3 has both eGFR and tHcy in the model. Adjusted models are adjusted for age, sex, SBP, smoking (in pack years), LDL, HDL and weight.