Table 3.

Detecting and quantifying mediating effect of homocysteine in the association between eGFR as independent variable and vascular outcomes

	P-value	% of total effect mediated	Ratio of the indirect to the direct effect
Unadjusted regression
Outcome = TPA	<0.0001	0.12	0.14
Outcome = stenosis	0.20	0.12	0.13
Adjusted regression
Outcome = TPA	0.03	0.31	0.44
Outcome = stenosis	0.16	0.31	0.45

TPA is in log scale.

P-values and mediation effects were computed from the Sobel test [20, 21].

Unadjusted regression included three covariates (exposure, mediator and outcome) in the model.

Adjusted regression further included age, sex, SBP, smoking (in pack years), LDL, HDL and weight in the model.