Table 1.
Participant characteristics at baseline, n (%) or mean ± standard deviation.
| Total (N = 233) |
APOE ε4 carriers (N = 70) |
APOE ε4 non-carriers (N = 157) |
p | TOMM40 VL/VL (N = 39) |
TOMM40 S/S (N = 40) |
p | |
|---|---|---|---|---|---|---|---|
| Age | 56.4 ± 9.8 | 57.1 ± 8.3 | 56.0 ± 10.5 | 0.44 | 57.0 ± 11.3 | 55.1 ± 10.5 | 0.46 |
| Female | 145 (62) | 43 (61) | 97 (62) | 0.96 | 25 (64) | 24 (60) | 0.71 |
| Caucasian | 230 (99) | 68 (97) | 156 (99) | 0.17 | N/A | N/A | N/A |
| Education | 17.0 ± 2.4 | 17.3 ± 2.2 | 16.9 ± 2.5 | 0.35 | 16.8 ± 2.4 | 16.9 ± 2.3 | 0.95 |
| Baseline glucose (mg/dL) | 98.6 ± 24.1 | 97.1 ± 17.9 | 99.4 ± 26.9 | 0.53 | 100.8 ± 34.5 | 101.4 ± 28.4 | 0.95 |
| Diabetes | 4 (2) | 0 (0) | 4 (3) | 0.17 | 0 (0) | 1 (3) | 0.32 |
| Cardiovascular conditions | 11 (5) | 4 (6) | 6 (4) | 0.56 | 3 (8) | 1 (3) | 0.29 |
| Hypertension | 29 (13) | 12 (17) | 17 (11) | 0.23 | 3 (8) | 3 (8) | 0.97 |
| Hypercholesterolemia | 31 (14) | 17 (24) | 14 (9) | 0.003 | 3 (8) | 4 (10) | 0.72 |
| Traumatic brain injury (TBI) | 4 (2) | 0 (0) | 4 (3) | 0.17 | 1 (3) | 0 (0) | 0.31 |
| Depression, ever | 44 (20) | 19 (27) | 23 (15) | 0.03 | 8 (21) | 6 (15) | 0.51 |
| Depression, within 2 years of baseline | 31 (14) | 15 (21) | 15 (10) | 0.02 | 8 (21) | 4 (10) | 0.21 |
| Logical Memory Immediate | 15.0 ± 3.2 | 15.1 ± 3.2 | 14.9 ± 3.2 | 0.82 | 15.1 ± 3.1 | 15.7 ± 2.4 | 0.46 |
| Logical Memory Delayed | 13.0 ± 3.8 | 13.2 ± 3.6 | 12.9 ± 4.0 | 0.67 | 12.8 ± 3.3 | 14.5 ± 2.9 | 0.09 |
| Logical Memory, % retention | 51.9 ± 15.4 | 52.7 ± 14.4 | 51.6 ± 15.8 | 0.67 | 51.3 ± 13.0 | 58.0 ± 11.6 | 0.09 |
| Paired Associate Immediate | 19.9 ± 3.6 | 20.3 ± 3.7 | 19.7 ± 3.6 | 0.39 | 20.0 ± 3.6 | 20.8 ± 2.8 | 0.48 |
| Paired Associate Delayed | 7.6 ± 0.8 | 7.6 ± 0.8 | 7.6 ± 0.9 | 0.86 | 7.6 ± 0.8 | 7.9 ± 0.5 | 0.16 |
| Rey Figure Recall | 18.9 ± 6.5 | 17.9 ± 6.5 | 19.4 ± 6.4 | 0.11 | 18.1 ± 7.1 | 19.8 ± 6.5 | 0.27 |
| Block Design Subtest | 33.2 ± 9.3 | 32.9 ± 10.2 | 33.3 ± 8.9 | 0.76 | 34.4 ± 8.6 | 33.7 ± 10.3 | 0.75 |
| Boston Naming Test, % correct | 93.6 ± 7.4 | 93.7 ± 5.6 | 93.6 ± 8.1 | 0.95 | 94.0 ± 5.4 | 94.6 ± 6.9 | 0.68 |
| Digit Symbol Test | 54.8 ± 11.0 | 56.8 ± 12.1 | 53.9 ± 10.4 | 0.05 | 54.1 ± 9.4 | 56.4 ± 11.6 | 0.35 |
Values presented as n (%) were compared between groups using chi-square tests; values presented as mean ± standard deviation were compared between groups using t-tests.
Bold numbers indicate significance at p < 0.05 level.