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. 2016 Jan 25;2:15069. doi: 10.1038/cddiscovery.2015.69

Figure 7.

Figure 7

Schematic showing how endocytosis, filopodia, VEGF/VEGFR2 regulate membrane traffic to execute the blebbishield emergency program. Left panel depicts the cellular level aspects of the blebbishield emergency program whereas right panel depicts organelle, and molecular-level events of the blebbishield emergency program. Molecules listed within yellow boxes are demonstrated to interact with the molecules identified by black boxes within. Red lines indicate events leading to either apoptosis or blocking survival whereas black lines indicate survival paths. NEM, N-ethylmaleimide; TGN, trans-Golgi network; BFA, brefeldin-A; NAb, neutralizing antibody; Cl. β-catenin, cleaved β-catenin; PMA, phorbol-myristic acetate; ER, endoplasmic reticulum; PM, plasma membrane; PTM, post-translational modification.