Figure 1.

Forest plot showing the effect of alleles previously associated with longer leukocyte telomere length on risk of (A) neuroblastoma (N = 1516), (B) osteosarcoma (N = 660) and (C) acute lymphoblastic leukemia (N = 958) compared with 6892 controls. Odds ratios > 1.0 indicate that the allele associated with longer telomere length is associated with an increased risk of cancer. Allelic odds ratios are plotted with 95% confidence intervals. The overall estimate is for the combined effect of all eight SNPs, where the odds ratio relates to the change in cancer risk for a one standard deviation increase in genotypically estimated leukocyte telomere length, with standard deviation determined in the controls.