Fig 1. Flowchart.

^aPeriod July 16, 2007 to July 31, 2011 (total births from July 1, 2007 to July 31, 2011 as originally described in the non CF-causing cohort publication was 2,178,829).⁸ IRT = immunoreactive trypsinogen. ^bCF-causing = group of children carrying CFTR mutations from the panel in trans with another panel mutation (n = 174) or with a sequenced mutation classified as CF-causing by CFTR2—July 2013 list (n = 60). Total of subjects in the CF-C group in previous publication of non CF-causing cohort was 226. [8] The difference is due to changes in CFTR2 classification from 2012 to 2013. VCC = group of children carrying CFTR mutations from the panel in trans with a sequenced mutation of varying clinical consequence. Unknown liability = group of children carrying CFTR mutations from the panel in trans with a sequenced mutation of unknown disease liability. ^c 5T = group of children carrying CFTR mutations from the panel in trans with / IVS8-(TG)m-5T subgroups (TG-13, 12, and 11) will be reported elsewhere.