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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: Chemistry. 2016 Mar 23;22(19):6491–6495. doi: 10.1002/chem.201600685

Figure 2.

Figure 2

Evaluation of CEST MRI. CEST signal amplitudes from the amide of the substrate, the amide of the product, and the salicylic acid moiety of the product are shown as circles, squares, and diamonds, respectively. a) A saturation time of 4 seconds was sufficient to generate a strong CEST signal from the substrate and product. b) A saturation power of 3 μT generated sufficiently strong CEST signal for detection. c) Extrapolation of the CEST-concentration relationship for the substrate showed that 1.3 mM of substrate can generate a 1% CEST signal. d) The CEST signal amplitude of the amides are dependent on pH, while the CEST signal from the salicylic acid moiety is relatively independent of pH.