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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Bioorg Med Chem Lett. 2015 Sep 5;26(5):1495–1497. doi: 10.1016/j.bmcl.2015.09.010

Table 1.

Antiproliferative Activity of Natural (1–10) and Synthetic (11–16, 20, 21) Alkaloids

Compd IC50 (µM)
R1 A549 KB KB-VIN MDA-MB-231 MCF7
1 >80 >80 >80 >80 >80
2–10 >40 >40 >40 >40 N/Da)
11 graphic file with name nihms758764t1.jpg >40 >40 >40 >40 N/D
12 graphic file with name nihms758764t2.jpg 42 ± 0.94 58 ± 2.1 72 ± 1.6 45 ± 7.8 54 ± 21
13 graphic file with name nihms758764t3.jpg 74 ± 1.9 74 ± 4.0 >80 67 ± 1.7 >80
14 graphic file with name nihms758764t4.jpg >80 71 ± 0.61 >80 68 ± 4.7 >80
15 graphic file with name nihms758764t5.jpg >40 >40 >40 >40 N/D
16 graphic file with name nihms758764t6.jpg >40 >40 >40 >40 N/D
20 graphic file with name nihms758764t7.jpg 17.6 ± 0.31 20.7 ± 0.56 21.6 ± 2.011 21.9 ± 0.54 20.5 ± 1.49
21 graphic file with name nihms758764t8.jpg >40 >40 >40 >40 N/D
PXL (nM)b 0.03 ± 0.03 0.04 ± 0.03 2600 ± 160 18 ± 3.2 3.9 ± 1.3
a

N/D: not determined.

b

: IC50 of paclitaxel (PXL) is represented in nM.