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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: J Med Chem. 2013 Nov 11;56(22):9045–9056. doi: 10.1021/jm400904m

Figure 3.

Figure 3

Reversal of NPS-induced suppression of palatable food intake.

Three groups (each N=7) of rats were treated with two successive, 10 min apart, 10 uL i.c.v. injections, of a) Vehicle (10µl 2% DMSO in distilled water) followed by vehicle (veh / veh); b) Vehicle followed by 10 µg NPS in vehicle (veh / NPS); and c) 10 µg 20e in vehicle followed by 10 µg NPS in vehicle (antagonist / NPS). Following the second injection, animals were placed back in their cages. Palatable food (17% H2O, 33% sweetened condensed milk, 51% rat chow) was introduced 20 min thereafter, and intake was measured at the timepoints indicated. #p<0.5 veh / NPS group vs. veh / veh group; *p<0.05 antagonist / NPS group vs. veh / NPS group.