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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: J Med Chem. 2013 Nov 11;56(22):9045–9056. doi: 10.1021/jm400904m

Scheme 2.

Scheme 2

aSynthetic Scheme towards tertiary alcohols 19a,b.

aReagents and conditions. a) NBS; b) iPrMgCl.LiCl, THF, Ph2CO, 18% yield for 18a, 31% for 18b; c) MeI, 1,4-dioxane, sealed tube, 100–120 °C, 50–60% yield.