Table 3.
SAR of substituted phenyl ring.
 | |||
|---|---|---|---|
| # | R | cAMP IC50 (µM) | Ca2+ IC50 (µM) |
| 20e |  |
0.044 ± 0.000 | 0.00096 ± 0.00023 |
| 21a |  |
0.11 ± 0.00 | 0.0032 ± 0.0005 |
| 21b |  |
0.094 ± 0.008 | 0.0034 ± 0.0016 |
| 21c |  |
0.22 ± 0.00 | 0.0092 ± 0.0029 |
| 21d |  |
0.12 ± 0.01 | 0.0022, 0.0071a |
| 21e |  |
0.40 ± 0.00 | 0.013, 0.0045a |
| 21f |  |
0.17 ± 0.01 | 0.0057 ± 0.0000 |
| 21g |  |
0.67 ± 0.05 | 0.023 ± 0.000 |
| 21h |  |
0.84 ± 0.07 | 0.045± 0.000 |
| 21i |  |
1.3 ± 0.0 | 0.064 ± 0.010 |
| 21j |  |
0.071 ± 0.000 | 0.0034 ± 0.0003 |
| 21k |  |
0.33 ± 0.03 | 0.0090 ± 0.0000 |
The cAMP and Ca2+ assay activity is the mean IC50 with SD from two separate experiments, each ran in duplicate.
a
Both IC50 values are reported here as we feel that the standard deviation between the replicates is significant.