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. Author manuscript; available in PMC: 2016 May 23.

Published in final edited form as: J Med Chem. 2013 Nov 11;56(22):9045–9056. doi: 10.1021/jm400904m

Table 5.

Mouse Pharmacokinetics of 20e³⁵ The concentration at each time point presented here is the mean derived from N=3.

	10 mpk IP

	Plasma			Brain

Sampling	Mean^a	SD	Mean	Mean^a	SD	Mean
time(hr)	ng/mL	ng/mL	nM	ng/g	ng/g	nmol/g
0	BQL	N/A	BQL	BQL	N/A	BQL
0.083	700	306	1503	14	2.41	30
0.25	617	111	1325	24	8.16	52
0.5	536	235	1150	25	3.57	53
1	259	5.03	556	21	5.14	44
2	180	7.64	386	27	6.95	57
4	114	18.3	245	24	3.31	53
8	99	34.6	214	28	8.06	60
12	58	9.66	126	43	17.8	93
24	25	4.33	54	24	2.45	52

^a

Mean from N=3