Figure 2.

Concentration of ECM remodeling markers in supernatants of PCKS. Levels of P1NP (formation of collagen type I) (A), C1M (MMP-mediated degradation of collagen type I) (B), C3M (MMP-mediated degradation of collagen type III) (C), and α-SMA (D) in PCKS from UUO-operated animals (right kidney: obstructed kidney; left kidney: contralateral kidney) and control sham-operated animals (sham).

Notes: Statistical difference calculated with Wilcoxon test (^***P < 0.001) or Mann–Whitney test (^##P < 0.01; ^####P < 0.0001). Data presented as mean ± SEM.