Table 2. Parameter estimates for the model with virus neutralisation, in which antibody removes virus (Model 2).
The model was separately fitted to IgM data for DENV1 and DENV2 infections. For immune response parameters and the incubation period which are patient specific parameters, median (IQR) and min and max are reported. For the group-level parameter δ, the median and (95% CI) are reported. Parameters z0, η1, η2, IP and SF were fitted as patient specific and others as common to all patients in the fitted group.
| Serotype | Parameter | Parameter Estimates |
|---|---|---|
| DENV1 | z0 | 0.121 [0.0401, 0.351] {1.70x10-3, 1.24} |
| η1 | 1.19 [1.03, 1.38] {0.496, 2.13} | |
| IP | 5.51 [4.68, 6.66] {3.88, 8.29} | |
| SF | 0.177 [0.0987, 0.293] {0.017, 1.41} | |
| η2 | 2.41x105 [7.63x104, 2.28x106] {1.40, 1.11x109} | |
| δ | 3.30 (3.07, 3.48) | |
| Log-likelihood | -539 | |
| DENV2 | z0 | 0.177 [0.0712, 0.471] {9.54x10-3, 0.941} |
| η1 | 1.04 [0.815, 1.22] {0.562, 1.99} | |
| IP | 5.57 [4.57, 6.44] {3.54, 7.86} | |
| SF | 0.151 [0.0616, 0.192] {0.0346, 0.748} | |
| η2 | 1.62x104 [4.42x103, 1.66x105] {41.6, 1.22x107} | |
| δ | 3.54 (3.38, 3.67) | |
| Log-likelihood | -647 |