Table 1.

Base-case values and ranges tested in sensitivity analyses

Base-case assumptions and ranges for sensitivity analysis, %
Events	Medical	Surgical
Seizure-free during first year	8 (0–16)	71.9 (69.5–74.3)
Relapse if seizure-free at end of year, from years 1 to 5	25.4 (10.9–46.2)	5.6 (2.9–8.3)
Relapse if seizure-free at end of year, after 5 years	25.4 (10.9–46.2)	4.2 (1.6–6.8)
Seizure remission if not seizure-free at end of year, from years 1 to 5	4.7 (3–7)	5.9 (0.9–11)
Seizure remission if not seizure-free at end of year, after 5 years	1.6 (1–2.3)	2.0 (0.2–7.2)
Surgical complications, %
Death		0.3 (0–0.75)
Permanent deficit (other than verbal memory loss)		4.0 (2.0–6.0)
Transient complication		8.0 (6.0–10)
Standardized mortality ratios
Seizure-free		1.11 (0.63–1.94)
Not seizure-free, surgery		5.64 (3.49–9.09)
Not seizure-free, medical management		5.40 (3.96–7.37)
Verbal memory decline, %
Predicted verbal memory decline accurate		100 (60–100)
Quality of life scores for model health states
Free of disabling seizures
Medical management		0.96 (0.84–1.0)
Surgery, without complications		0.97 (0.87–1.0)
Surgery, permanent complication		0.77 (0.32–1.0)
Surgery, transient complication		0.96 (0.84–1.0)
Not free of disabling seizures
Medical management		0.75 (0.38–1.0)
Surgery, without complications		0.75 (0.41–1.0)
Surgery, permanent complication		0.66 (0.19–1.0)
Surgery, transient complication		0.75 (0.38–1.0)
Transient surgical complication, days of life deducted		1.5 (0–25.0)
Quality of life penalty for memory loss
Severe		0.4
Moderate		0.25
Mild		0.1