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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2015 May 26;12(6):342–352. doi: 10.1038/nrgastro.2015.74

Figure 1.

Figure 1

Cellular targets and molecular events after RRV infection. When administered into BALB/c mice in the first 2 postnatal days, RRV infects cholangiocytes, inducing apoptosis and necrosis. RRV also targets hepatic DCs, which activate NK cells via Il-15 and hepatic macrophages, which secrete Cxcl2 that attracts neutrophils. Abbreviations: Cxcl2, C-X-C motif chemokine 2; NK, natural killer cell; RRV, Rhesus rotavirus type A.