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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: N Engl J Med. 2013 Jul 11;369(2):155–163. doi: 10.1056/NEJMoa1209165

Table 1.

All cause pneumonia rates and characteristics Pre-PCV7 (1997–1999) versus late PCV7 (2007–2009)

Pneumonia rates and characteristics Time period Age Group (years)
<2 2–4 5–17 18–39 40–64 65–74 75–84 85+

Average annual hospitalizations per 100,000 Pre-PCV7 1274
(1185–1364)
411
(383–439)
97
(91–104)
107
(102–113)
336
(321–351)
1293
(1239–1348)
2758
(2643–2873)
5697
(5457–5937)

Late PCV7 723
(666–780)
360
(329–391)
93
(85–101)
99
(93–104)
370
(351–388)
1208
(1152–1264)
2398
(2287–2510)
4396
(4189–4603)

Median (IQR) stay in days Pre-PCV7 2.3
(1.4–3.6)
2.0
(1.2–3.1)
2.3
(1.4–3.8)
3.2
(1.9–5.4)
4.0
(2.4–6.6)
4.6
(2.8–7.5)
4.9
(3.0–7.9)
5.2
(3.2–8.2)

Late PCV7 1.9
(1.1–3.2)
1.8
(1.1–2.9)
2.0
(1.2–3.6)
3.0
(1.7–5.7)
3.8
(2.1–6.9)
4.2
(2.4–7.4)
4.3
(2.6–7.5)
4.4
(2.6–7.2)

% Coded as pneumococcal Pre-PCV7 2.2
(1.9–2.5)
3.2
(2.8–3.5)
4.2
(3.9–4.6)
8.4
(7.6–9.2)
7.4
(7.0–7.8)
5.6
(5.4–5.8)
4.6
(4.5–4.8)
3.7
(3.6–3.9)

Late PCV7 1.5
(1.3–1.7)
2.7
(2.3–3)
2.9
(2.6–3.2)
4.6
(4.4–4.8)
4.8
(4.6–4.9)
3.5
(3.3–3.6)
2.6
(2.5–2.7)
2.2
(2.1–2.4)

% In-hospital death Pre-PCV7 0.2
(0.2–0.3)
0.2
(0.1–0.3)
0.4
(0.3–0.5)
1.8
(1.6–1.9)
4.3
(4.2–4.5)
6.8
(6.7–7.0)
9.3
(9.2–9.4)
13.0
(12.8–13.2)

Late PCV7 0.2
(0.1–0.2)
0.1
(0.1–0.2)
0.4
(0.3–0.5)
2.2
(2–2.4)
4.9
(4.7–5.1)
7.0
(6.9–7.2)
8.7
(8.6–8.8)
11.5
(11.3–11.7)