Table 1.

Measures of test performance between the STK11 signature and detected DNA variation in TCGA and the MLOS cohorts

	Detected DNA Variation	Signature Prediction	N	Class	Metric	Value	95% CI
TCGA
	Mutant	STK11+	71	TP (True Positives)	Sensitivity	0.947	(0.869, 0.985)
	Mutant	WT	4	FN (False Negatives)	Specificity	0.732	(0.686, 0.77)
	WT	STK11+	109	FP (False Positives)	Precision	0.394	(0.322, 0.469)
	WT	WT	298	TN (True Negatives)	NPV (Negative Predictive Value)	0.987	(0.966, 0.996)
					False Positive Rate	0.268	(0.22, 0.313)
					False Discovery Rate	0.606	(0.53, 0.677)
MLOS
	Mutant	STK11+	66	TP (True Positives)	Sensitivity	0.971	(0.897, 0.996)
	Mutant	WT	2	FN (False Negatives)	Specificity	0.741	(0.693, 0.784)
	WT	STK11+	97	FP (False Positives)	Precision	0.405	(0.328, 0.484)
	WT	WT	277	TN (True Negatives)	NPV (Negative Predictive Value)	0.993	(0.974, 0.999)
					False Positive Rate	0.259	(0.215, 0.306)
					False Discovery Rate	0.595	(0.515, 0.671)