Table 2.
STK11 IHC results and test performance comparison with the STK11 NanoString Assay
| Number of Patient’s with indicated IHC scores | ||||||
| IHC Pathology Score | 0 | +1 | +2 | +3 | +4 | |
| Normal Cores | 0 | 0 | 0 | 3 | 51 | |
| Carcinomas | ||||||
| STK11 Mutant | 7 | 6 | 2 | 5 | 7 | |
| STK11 WT | 15 | 6 | 6 | 18 | 68 | |
| Receiver-operator characteristics modeling | ||||||
| Model | AUC | 95% | Difference in AUC and 95% CI | p-value | ||
| NanoString | 0.8377 | (0.76, 0.9154) | 0.1588 (0.035, 0.2825) | 0.0119 | ||
| IHC Pathology Score | 0.6789 | (0.566, 0.7918) | ||||