Table 3.
Cotinine group and risk of coronary heart disease (CHD): hazard ratios (95% confidence intervals) for specific 5 year follow up periods
|
Follow up period (years)
|
||||
|---|---|---|---|---|
| 0-4 | 5-9 | 10-14 | 15-20 | |
| Passive smokers*† | ||||
| Adjustment 1 | 3.45 (1.36 to 8.80) | 1.90 (1.09 to 3.31) | 1.27 (0.72 to 2.22) | 1.09 (0.66 to 1.82) |
| Adjustment 2 | 3.14 (1.23 to 8.04) | 1.93 (1.09 to 3.42) | 1.10 (0.63 to 1.95) | 1.00 (0.60 to 1.67) |
| Adjustment 3 | 3.73 (1.32 to 10.58) | 1.95 (1.09 to 3.48) | 1.13 (0.63 to 2.04) | 1.04 (0.62to 1.76) |
| Low active smokers†‡ | ||||
| Adjustment 1 | 3.44 (1.07 to 11.02) | 1.50 (0.63 to 3.55) | 1.59 (0.70 to 3.62) | 1.41 (0.66 to 3.03) |
| Adjustment 2 | 2.99 (0.90 to 9.97) | 1.58 (0.66 to 3.80) | 1.43 (0.61 to 3.38) | 1.47 (0.68 to 3.15) |
| Adjustment 3 | 3.32 (0.87 to 12.64) | 1.66 (0.66 to 4.18) | 1.71 (0.71 to 4.10) | 1.34 (1.23 to 1.47) |
Hazard ratios for CHD events for passive smokers with cotinine above 0.7 v passive smokers with cotinine below 0.7.
For CHD: adjustment 1 stratified by town and adjusted for age; adjustment 2 additionally adjusted for systolic blood pressure, diastolic blood pressure, total cholesterol, HDL cholesterol, FEV1, height, and pre-existing CHD; adjustment 3 additionally adjusted for BMI, triglycerides, white cell count, diabetes, physical activity (none, occasional, light, moderate or more), alcohol intake (none/occasional, light/moderate, heavy), and social class (I, II, III non-manual, III manual, IV, V, and Armed Forces).
Hazard ratios for CHD events for low active smokers (1-9 cigarettes/day) v passive smokers with cotinine below 0.7.