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. 2016 May 24;10:48. doi: 10.3389/fncom.2016.00048

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Copyright © 2016 Zakharov, Lapish, Gutkin and Kuznetsov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NMDAR current (g_A = 0) increases the firing frequency above 20 Hz (A) whereas AMPA (g_N = 0) evokes a much smaller frequency increase and provokes depolarization block (B) in the minimal model of DA neuron (Equation 1). Spikes are registered as the voltage oscillation crosses the threshold of −0.4 (dimensionless units).