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. 2016 May 24;10:48. doi: 10.3389/fncom.2016.00048

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Copyright © 2016 Zakharov, Lapish, Gutkin and Kuznetsov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-activation of AMPA and NMDA receptor currents allow one to reach a significantly higher frequencies. (A) Dependence of the frequency in the minimal model (Equation 1) on the conductance of NMDA current g_N for the different values of g_A. The curves correspond to horizontal slices of the Figure 4. (B) The maximum frequency calculated over the whole range of g_N for each value of g_A. The additional frequency growth exceeds 20%. The intrinsic frequency in the graph corresponds to the tonic firing without any external stimulus.