Table 3.

VBM results showing regions of significant gray matter intensity decrease in AD and bvFTD patients relative to controls.

Contrast	Regions	Side	Number of voxels	MNI coordinates
				x	y	z
AD vs. Controls	Temporal pole, temporal fusiform cortex, OFC, parahippocampal cortex, amygdala, hippocampus, thalamus, insular cortex, parietal operculum cortex, supramarginal gyrus, angular gyrus, occipital cortex, precuneus cortex	L	9,713	-28	4	-48
	Inferior/middle frontal gyrus, insular cortex, paracingulate gyrus, anterior cingulate cortex, posterior cingulate cortex	L	2,720	-40	14	22
	Lateral occipital cortex	R	2,166	46	-86	6
	Paracingulate gyrus, medial PFC, anterior cingulate cortex	R	1,588	14	48	-4
	Frontal pole, medial PFC, OFC	L	452	-14	56	-10
	Temporal pole, temporal fusiform cortex	R	318	34	6	-42
	Cerebellum	L	199	-46	-56	-36
	Juxtapositional lobule, superior frontal gyrus	L	142	-4	4	72
	Hippocampus, amygdala	R	107	26	-12	-16
bvFTD vs. Controls	Cerebellum extending into temporal fusiform cortex, temporal pole, parahippocampal cortex, amygdala, hippocampus, insular cortex, OFC, medial PFC, anterior cingulate cortex, paracingulate gyrus, frontal pole	B	38,955	-32	-76	-58
	Cerebellum	R	5,183	50	-58	-50
	Angular gyrus, lateral occipital cortex	R	1,050	48	-54	20
	Precentral gyrus, middle frontal gyrus	R	463	44	-2	38
	Supramarginal gyrus, superior temporal gyrus	L	402	-48	-44	10
	Cerebellum	R	291	6	-46	-22
	Middle frontal gyrus	R	114	46	14	52
	Precentral gyrus	L	100	-18	-28	42

MRI scan not available for one Control participant. Age included as a covariate in all contrasts. All clusters reported using the threshold free cluster enhancement method (tfce) and corrected for Family Wise Error (FWE) at p < 0.05. For brevity, only clusters above 100 contiguous voxels are reported. All clusters reported t > 1.70. OFC, orbitofrontal cortex; PFC, prefrontal cortex; L, left; R, right; B, bilateral; MNI, Montreal Neurological Institute.