Table 1.

Input estimates used in the analysis

Item	Value
Program invitation per person invited (one-off invitation letter and infrastructure cost)	£5
Cost of providing polypill (per person per day)c	£0.50, 0.75, 1.00, 1.25 and 1.50
Average healthcare cost of an MI (per clinical event)c	£29,900 [11, 15]
Average healthcare cost of a stroke (per clinical event)c	£50,500 [12]
Polypill uptake	50 %
Polypill adherence	83 % [14]
Polypill LDL cholesterol reductiona	1.54 mmol/L [5]
Polypill diastolic BP reductiona	10.7 mmHg [6]
Age-specific relative risk for MI on polypill at age 60b	0.23 [5, 16]
Age-specific relative risk for stroke on polypill at age 60b	0.28 [5, 6, 16]

^aSimvastatin 20 mg, amlodipine 2.5 mg, hydrochlorothiazide 12.5 mg, losartan 25 mg

^bAge-specific relative risks from age 50 were applied in the model

^cAt 2014 prices