Figure 7. Administration of therapeutic doses of bioengineered miR-34a prodrug had no significant effects on mouse blood chemistry profiles including alanine transaminase (ALT), aspartate transaminase (AST), total protein, albumin, total bilirubin, alkaline phosphatase (ALP), blood urea nitrogen (BUN), and creatinine levels, as compared to vehicle or tRNA/MSA treatment.

The ranges of individual markers (derived from BALB/c mice; Comparative Pathology Laboratory at UC-Davis) were labeled as a reference. Values are mean ± SD (N = 3 in each group).