TABLE 1.

Serum adipokine and cytokine concentrations in mice fed 1 of 4 diets containing 2 amounts of salt and fat for 12 wk¹

					P
	LF	LF+NaCl	HF	HF+NaCl	Fat	Salt	Fat × salt interaction
IL-1β, pg/mL	12.7 ± 6.31	18.8 ± 9.78	16.4 ± 6.77	13.7 ± 5.23	0.48	0.40	0.27
IL-4, pg/mL	118 ± 21.4	157 ± 69.8	200 ± 44.5	216 ± 52.4	0.08	0.28	0.40
IL-6, pg/mL	103 ± 25.3	167 ± 16.1	167 ± 37.1	124 ± 15.3	0.36	0.36	0.04
IL-17a, ng/mL	1.71 ± 0.32b	1.38 ± 0.33b	2.76 ± 0.40a	2.08 ± 0.36a,b	0.02	0.10	0.33
IL-18, pg/mL	275 ± 11.2	278 ± 14.2	260 ± 1.80	260 ± 7.29	0.05	0.44	0.42
TNF-α, pg/mL	7.46 ± 1.17b	11.1 ± 2.42a,b	15.9 ± 2.11a	16.5 ± 3.79a	0.01	0.22	0.29
IFN-γ, pg/mL	479 ± 106b	565 ± 96.7a,b	906 ± 61.6a	723 ± 96.9a,b	<0.01	0.31	0.09
Resistin, ng/mL	57.6 ± 9.79	38.8 ± 27.3	73.3 ± 21.3	59.9 ± 12.4	0.16	0.19	0.44
Leptin, ng/mL	28.3 ± 3.23b,c	20.7 ± 3.88c	64.5 ± 2.83a	60.5 ± 5.72a,b	<0.01	0.10	0.34
Adiponectin, μg/mL	7.63 ± 0.32a	6.67 ± 0.31a,b	5.54 ± 0.33b	6.83 ± 0.38a,b	<0.01	0.31	<0.01
Renin I, ng/mL	1.29 ± 0.18a,b	1.00 ± 0.15a,b	1.53 ± 0.28a	0.83 ± 0.10b	0.44	0.02	0.29

¹Values are means ± SEMs, n = 6–7 mice/group. Labeled means in a row without a common superscript letter differ, P < 0.05. HF, high-fat; HF+NaCl, high-fat with high-salt; LF, low-fat; LF+NaCl, low-fat with high-salt.