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. 2016 Apr 11;5(6):422–432. doi: 10.1016/j.molmet.2016.04.001

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Adipocyte Raptor KO mice are resistant to HFD obesity but suffer from more severe hepatic steatosis. (A) Body weight, and weight gain of mice over course of HFD. (B) Body weight and body composition after ∼4 weeks HFD. (C) Representative images of inguinal fat depots after HFD. (D) Adipose depot masses at the end of HFD course. (E) Fold increase in WAT depot mass after HFD feeding. (F) Representative H&E images of specified tissues before and after HFD. (G) Lean tissue mass after HFD. (H) Representative images of liver after HFD. (I) Liver/BW ratio of mice after HFD. (J) Representative ORO staining of liver samples after HFD. (Data were analyzed by Student's t-test. Values expressed as mean + SEM. *p < 0.05; **p < 0.01; ***p < 0.001).