Table 1.

Body-weight change of rats following repeated daily oral doses of lamivudine for 45 days^*

Lamivudine dose (mg/Kg/day)	Initial weight (g)	Final weight (g)	Weight change (%)
0.0	158.7 ± 2.62	208.2 ± 4.74	+31.2 ± 1.14
4.0	140.4 ± 2.45	177.7 ± 6.04†	+28.0 ± 1.14
20.0	117.0 ± 4.04	142.4 ± 7.14†	+21.3 ± 2.12
100.0	163.4 ± 3.80	197.9 ± 6.41†	+21.0 ± 1.25
500.0	150.1 ± 4.78	172.1 ± 7.31†	+14.5 ± 1.47

^*Values are means ± S.E.M.

^†Means significantly different when compared with the control P<0.05 otherwise p>0.05 (Paired t- test).