Table 2.

Sera of rats following daily oral doses of 3TC for 45 days^*

Lamivudine dose (mg/kg/d)	ALT (I.U/L)	AST (I.U/L)	GGT (I.U/L)	Total Protein (mg/ml)
0.0	23.3087 ±1.51	42.5710 ± 1.96	14.3075±0.72	6.134 ± 0.61
4.0	25.0575 ± 1.31	43.1957 ± 1.18	13.8633 ± 0.81	6.186 ± 0.35
20.0	27.7433 ± 1.99	43.4660 ± 1.38	15.2150 ± 1.12	5.325 ± 0.34
100.0	28.4802 ± 2.53	44.7498 ± 2.34	15.8780 ± 2.65	4.791 ± 0.45
500.0	33.1847 ± 3.96†	56.4205±7.17†	16.2613 ± 1.78†	3.945 ± 0.20‡

^*Values are means ± S.E.M. Mean significantly different from the control

^†p<0.05;

^‡p<0.01, otherwise p>0.05.