Table 4.

Malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) specific activities in the rat livers following daily oral doses of 3TC for 45 days^#

Lamivudinedose (mg/kg/day)	Hepatic-MDA concentration (nmole/mg protein)	Hepatic SOD specific activity-(U/mg protein)
0.0	0.0571 ± 0.01	9.9583 ± 0.70
4.0	0.0730 ± 0.01	12.0100 ± 0.93
20.0	0.1560 ± 0.03	14.7017 ± 1.49*
100.0	0.1647 ± 0.03†	14.7383 ± 1.20*
500.0	0.2228 ± 0.04* ‡	16.5267 ± 1.32*∆

^#Values are means ± S.E.M. Mean significantly different from the control

^†p<0.05,

^*p<0.01 and different from 4mg/kg,

^∆p<0.05, ‡p<0.01, otherwise p>0.05 when compared with the control.