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Effect of the betaine and sodium-4-phenylbutyrate on FVIII secretion. HEK 293 cells expressing FVIIIΔB or FVIIIΔB-F309S were incubated with betaine and sodium-4-phenylbutyrate alone or in combination. FVIII activity was determined in cell supernatants after 72 h by chromogenic assay (n = 3). aStatistically significant differences between groups using two-way ANOVA. p-Value = 0.0045. bStatistically significant differences between groups using two-way ANOVA. p-Value = 0.0005.
