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. 2016 May 24;8:57. doi: 10.1186/s13148-016-0223-4

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© Morera et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Schematic view of DOT1L principal domains. b Structures of the methyl donor SAM, its enzymatic product SAH and of two DOT1L inhibitors. The SAM-like shared moiety is highlighted in bold