Table 2.
Effect of Mammea africana stembark on liver functions in paracetamol-intoxicated rats
|
Parameters/
Treatment |
Total protein
(g/dl) |
Albumin
(g/dl) |
Total bilirubin
(µMol/l) |
Direct
Bilirubin (µMol/l) |
AST
(U/L) |
ALT
(U/L) |
ALP
(U/L) |
Total cholesterol |
|---|---|---|---|---|---|---|---|---|
| Normal control | 6.98 ± 0.14 | 4.25 ± 0.15 | 5.02 ± 2.81f | 2.08 ± 2.67 | 66.42 ± 10.21 | 26.16 ± 1.77 | 107.98 ± 6.50 | 80.86 ± 1.23 |
| PCM +Dist. water | 3.18 ± 0.42c | 1.64 ± 0.65c | 16.88 ± 3.48c | 10.54 ± 3.08c | 153.40 ± 18.87c | 62.18 ± 12.32c | 180.54 ± 27.56c | 154.6 ± 3.12c |
| MA. 30mg/kg + PCM | 4.95 ± 0.44a | 2.86 ± 0.24d | 11.62 ± 2.29e | 7.68 ± 2.08b | 123.96 ± 8.01cf | 51.88 ± 4.70cf | 165.18 ± 12.94cf | 128.5 ± 2.87cf |
| MA. 60mg/kg+ PCM | 7.13 ± 0.33e | 3.56 ± 0.28e | 9.18 ± 1.81f | 5.18 ± 2.15f | 92.06 ± 8.34af | 37.36 ± 8.84cf | 140.08 ± 36.31f | 88.22 ± 3.42bf |
| MA. 90mg/kg+ PCM | 7.04 ± 0.66f | 3.94 ± 0.48f | 5.92 ± 1.31c | 3.78 ± 1.56f | 91.74 ± 10.01f | 36.14 ± 2.58ef | 119.02 ± 12.86f | 74.43 ± 1.13f |
| Silymarin 100mg/kg + PCM | 7.16 ± 0.32f | 4.06 ± 0.25f | 6.21 ± 1.16e | 2.26 ± 0.75f | 95.60 ± 20.56f | 66.16 ± 10.56f | 196.28 ± 28.42 | 78.33 ± 1.96f |
Data were expressed as mean SEM.
a
(p<0.05),
b
(p<0.01),
c
(p<0.001) represent the level of significance when compared to control.
d
(p<0.05),
e
(p<0.01)
f
(p<0.001) represent the level of significance when compared to paracetamol n = 6).