Table 4.
Effect of Mammea africana stembark extract on liver antioxidant enzymes in paracetamol-intoxicated rats.
|
Parameters/
Treatment |
SOD
(U/mg of protein) |
CAT
(U/mg of protein) |
GPx
(U/mg of protein) |
GSH
(µg/mg of protein) |
|---|---|---|---|---|
| Normal control | 22.86 ± 0.53 | 55.68 ± 1.86 | 26.42 ± 0.66 | 0.35 ± 0.02 |
| PCM +Dist. Water | 9.85 ± 0.16c | 25.40 ± 1.64c | 10.55 ± 0.42c | 0.14 ± 0.01c |
| MA. 30mg/kg + PCM | 12.82 ± 0.24cd | 41.02 ± 1.38cd | 16.04 ± 0.54c | 0.20 ± 0.01ce |
| MA. 60mg/kg+ PCM | 16.65 ± 0.65bf | 46.15 ± 1.41f | 22.86 ± 0.25cf | 0.25 ± 0.02bf |
| MA. 90mg/kg+ PCM | 20.09 ± 0.87cf | 51.04 ± 1.22f | 24.24 ± 1.65bf | 0.29 ± 0.01af |
| Silymarin 100mg/kg + PCM | 21.66 ± 0.14cf | 53.53 ± 2.12f | 25.86 ± 1.14f | 0.33 ± 0.02f |
Data were expressed as mean SEM.
a
(p<0.05),
b
(p<0.01),
c
(p<0.001) represent the level of significance when compared to control.
d
(p<0.05),
e
(p<0.01)
f
(p<0.001) represent the level of significance when compared to paracetamol (n = 6).