Table 1.

Patient-specific expression of cytokine and receptor genes by tumor cells complementing the signaling networks constructed in Figs. 4 and 6

Gene	Description	Min. TPM	Max. TPM
Cytokines
BMP8B	Bone morphogenetic protein 8b	0.32	32.17
CXCL6	Chemokine (C-X-C motif) ligand 6	0.00	7.74
CXCL14	Chemokine (C-X-C motif) ligand 14	0.00	5.74
DKK1	Dickkopf WNT signaling pathway inhibitor 1	0.00	7.49
EFNA3	Ephrin-A3	0.95	16.74
EGF	Epidermal growth factor	0.09	10.16
FGF2	Fibroblast growth factor 2 (basic)	0.02	29.35
FGF9	Fibroblast growth factor 9	0.08	15.31
FGF11	Fibroblast growth factor 11	0.48	6.17
FGF13	Fibroblast growth factor 13	0.08	9.04
FGFBP1	Fibroblast growth factor binding protein 1	0.00	28.97
KITLG	KIT ligand	0.04	7.48
NDP	Norrin (Norrie disease pseudoglioma)	0.00	5.44
NRG1	Neuregulin 1	0.02	5.23
NRG2	Neuregulin 2	0.04	4.59
NRG3	Neuregulin 3	0.00	13.39
PDGFD	Platelet derived growth factor D	0.29	6.58
RSPO3	R-spondin 3	0.02	8.90
S100A7	S100 calcium binding protein A7	0.00	4.03
S100P	S100 calcium binding protein P	0.00	12.00
SEMA3D	Semaphorin 3D	0.00	6.07
SEMA3E	Semaphorin 3E	0.13	93.32
SEMA4G	Semaphorin 4G	0.16	6.74
SEMA5B	Semaphorin 5B	0.03	19.94
SEMA6C	Semaphorin 6C	0.68	4.76
SEMA7A	Semaphorin 7A	0.26	9.55
SFRP1	Secreted frizzled-related protein 1	0.00	527.58
TGFB3	Transforming growth factor, beta 3	0.07	4.51
Cytokine receptors
AGER	Advanced glycosylation end product receptor	0.30	5.01
EPHA6	EPH receptor A6	0.13	25.52
FGFR4	Fibroblast growth factor receptor 4	0.33	3.76
FZD2	Frizzled family receptor 2	0.22	6.18
FZD10	Frizzled family receptor 10	0.00	7.95
IL10RA	Interleukin 10 receptor, alpha	0.00	5.91
Lipid mediators
ALOX15B	Arachidonate 15-lipoxygenase, type B	0.06	8.03
Lipid receptors
LTB4R2	Leukotriene B4 receptor 2	1.11	3.78
PTGER3	Prostaglandin E receptor 3 (subtype EP3)	0.10	11.87