Figure 6. Meox2 haploinsufficiency induces endothelial cell loss in B6.APBTg.Mx−/+ mice.
(A) Representative images of CD31-immunolabeled endothelial cells in the cortex and hippocampal CA1. (B) Quantitative analysis of CD31+ microvessel length in the cortex of B6, APB, B6.Mx−/+ and B6.APBTg.Mx−/+ mice at 10 and 14 months of age. (C) Quantitative analysis of CD31+ microvessel length in the hippocampal CA1 at 10 and 14 months of age. In (B-C) values are mean ± SEM, n= 4 mice per group, *P< 0.05, **P< 0.01, and ***P< 0.001 by one-way ANOVA. Scale bars: 50μm in (A).