Table 3.

ORR According to Pretreatment Characteristics

Characteristic	No.	ORR (%)	P
All patients	59	66
Age, years			1.00
< 65	34	65
≥ 65	25	68
Rai stage			.18
I-II	31	71
III-IV	28	54
Maximum lymph node size, cm			.07
< 5	49	67
≥ 5	10	40
β2-microglobulin, mg/L			.16
< 4.0	34	74
≥ 4.0	24	54
FISH hierarchy (n = 58)
13q deletion	9	67
Negative	11	55
Trisomy 12	7	71
11q deletion	16	69
17p deletion	15	53	.35*
CD38, % (n = 57)			.57
< 30	19	73
≥ 30	20	65
IGHV mutation status (n = 57)			.34
Mutated	14	79
Unmutated	43	60
No. of prior treatments			.16
1-2	35	74
≥ 3	24	54
Fludarabine			.041
Not refractory	47	70
Refractory	12	33

Abbreviations: FISH, fluorescent in situ hybridization; IGHV, immunoglobulin variable heavy chain; ORR, overall response rate.

^*17p deletion versus no 17p deletion.