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. 2012 Dec 26;31(5):584–591. doi: 10.1200/JCO.2012.42.8623

Table 5.

Other Nonhematologic/Noninfectious Toxicity

Toxicity* Grade 1-2
Grade 3-4
No. % No. %
Renal failure 0 0 1 1.7
Acute myocardial infarction 0 0 1 1.7
Tumor lysis syndrome 0 0 1 1.7
Pain (abdomen) 0 0 1 1.7
Venous thrombosis 0 0 1 1.7
Weakness 0 0 1 1.7
Fatigue 24 41 8 14
Diarrhea 21 36 1 1.7
Tumor flare 16 27 0 0
Sensory neuropathy 14 24 0 0
Rash 13 22 0 0
Constipation 11 20 1 1.7
Nausea 10 19 0 0
Neurologic (other) 10 17 0 0
Arthralgia 9 17 1 1.7
Anorexia 9 15 0 0
Metabolic or laboratory 9 15 0 0
Hyperglycemia 8 15 0 0
Pruritus 8 14 0 0
Elevated serum creatinine 7 14 0 0
GI pain 7 12 0 0
Hypomagnesemia 7 12 0 0
Hyperbilirubinemia 6 12 1 1.7
Dyspnea 6 10 0 0
Peripheral edema 6 10 0 0
Heartburn 6 10 0 0
Headache 6 10 0 0
*

Toxicity listed if any grade 3 or 4, or grade 1 or 2 in ≥ 10% of patients.

One patient developed grade 4 acute renal failure after tumor flare reaction complicated by acute myocardial infarction; all other nonhematologic toxicities were grade ≤ 3.