Table 5.

Other Nonhematologic/Noninfectious Toxicity

Toxicity*	Grade 1-2		Grade 3-4
	No.	%	No.	%
Renal failure†	0	0	1	1.7
Acute myocardial infarction†	0	0	1	1.7
Tumor lysis syndrome	0	0	1	1.7
Pain (abdomen)	0	0	1	1.7
Venous thrombosis	0	0	1	1.7
Weakness	0	0	1	1.7
Fatigue	24	41	8	14
Diarrhea	21	36	1	1.7
Tumor flare	16	27	0	0
Sensory neuropathy	14	24	0	0
Rash	13	22	0	0
Constipation	11	20	1	1.7
Nausea	10	19	0	0
Neurologic (other)	10	17	0	0
Arthralgia	9	17	1	1.7
Anorexia	9	15	0	0
Metabolic or laboratory	9	15	0	0
Hyperglycemia	8	15	0	0
Pruritus	8	14	0	0
Elevated serum creatinine	7	14	0	0
GI pain	7	12	0	0
Hypomagnesemia	7	12	0	0
Hyperbilirubinemia	6	12	1	1.7
Dyspnea	6	10	0	0
Peripheral edema	6	10	0	0
Heartburn	6	10	0	0
Headache	6	10	0	0

^*Toxicity listed if any grade 3 or 4, or grade 1 or 2 in ≥ 10% of patients.

^†One patient developed grade 4 acute renal failure after tumor flare reaction complicated by acute myocardial infarction; all other nonhematologic toxicities were grade ≤ 3.