Table 1.

Patient Characteristics by TP53 Mutational Status

Variable	Discovery Cohort				P	Validation Cohort				P
	TP53 Mutant		TP53 Wild Type			TP53 Mutant		TP53 Wild Type
	No.	%	No.	%		No.	%	No.	%
No.	41		356			22		134
Age, years
Median	11.7		10.65			10.7		12.1
Range	1-45		0-52			1.8-33		0-56
Age < 3	2	4.9	60	16.8	.04	1	4.5	43	32.1	.009
Adults > 18	4	9.8	60	16.9	.4	4	18.2	30	22.4	.8
Male sex	18	43.9	213	60	.07	10	47.6	73	55.3	.7
Histology					< .001					.002
LCA	17	42.5	43	12.3		8	44.4	14	10.7
Classic	22	55.0	254	72.8		8	44.4	68	59.8
Desmoplastic	1	2.5	52	14.9		2	11.1	33	29.5
M+ disease	4	10.5	110	31.9	.005	5	25	21	18.3	.5
Recurrence	24	58.5	114	32.0	.003	NA		NA
Dead	18	43.9	82	23.0	.011	9	40.9	27	20.1	.03
Subgroup					< .001					.28
WNT	11	26.8	55	15.4		7	31.8	28	20.9
SHH	28	68.3	105	29.5		15	68.2	106	79.1
Group 3	0		72	20.3
Group 4	1	2.4	121	34
Missing	1		3	0.8

NOTE. Histology was available for 389 cases in the discovery and 130 cases in the validation cohorts. Metastatic status at diagnosis was available in 269 cases in the discovery and 135 cases in the validation cohorts.

Abbreviations: LCA, large cell/anaplastic; NA, not applicable; SHH, sonic hedgehog; WNT, wingless.