Table 2.

Multivariate Cox Proportional Hazards Regression Models of Overall Survival in SHH Subgroup Medulloblastoma

Variable	Hazard Ratio	95% CI	BIF	P
Discovery cohort
TP53 mutation	4.39	1.70 to 11.29	95.7	.002
LCA v classic	1.07	0.39 to 2.90	20.9	.90
Desmoplastic v classic	0.45	0.17 to 1.22	54.0	.11
Sex (male v female)	1.21	0.56 to 2.58	24.3	.63
M+	0.38	0.11 to 1.37	58.6	.14
Age < 3 years	1.41	0.51 to 3.87	25.1	.51
Validation cohort
TP53 mutation	14.7	3.44 to 62.9	97.6	< .001
LCA v classic	2.90	0.79 to 10.6	47.1	.11
Desmoplastic v classic	0.41	0.08 to 2.14	43.9	.29
Sex (male v female)	0.71	0.24 to 2.11	24.4	.54
M+	26.4	5.96 to 117.5	99.4	< .001
Age < 3 years	4.15	0.93 to 18.6	60.7	.062

Abbreviations: BIF, bootstrap inclusion frequency; LCA, large cell/anaplastic; SHH, sonic hedgehog.