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. 2016 May 23;15:34. doi: 10.1186/s12941-016-0150-4

Table 2.

Quinolone MIC values of medically relevant pathogens

Organism Antibacterial agents MIC range MIC90 Ref.
S. pneumoniae Avarofloxacin 0.06–0.5 0.25 [10]
ciprofloxacin 8–64 64 [10]
Delafloxacin n.a. n.a. n.a.
Finafloxacin 0.5–4 2 [41]
Zabofloxacin 0.015–0.06 0.03 [24]
Nemonoxacin 0.03–1 0.06 [34]
S. aureus, MRSA FQ-resistant Avarofloxacin 0.015–2 0.25 [10]
Ciprofloxacin 4 ≥ 256 64 [10]
Delafloxacin ≤0.004–0.12 0.06 [15]
Finafloxacin 0.25–32 4 [41]
Zabofloxacin 0.016–64 32 [26]
Nemonoxacin 0.5–1 1 [34]
S. aureus, MRSA FQ-susceptible Avarofloxacin 0.008–0.015 0.008 [42]
Ciprofloxacin 0.25–1 0.5 [42]
Delafloxacin 0.008–1 0.5 [13]
Finafloxacin 0.06–0.125 0.125 [41]
Zabofloxacin 0.016–1 0.125 [26]
Nemonoxacin ≤0.008–0.12 0.06 [31]
E. faecalis Avarofloxacin 0.03–1 0.5 [10]
Ciprofloxacin 0.5–>16 >16 [10]
Delafloxacin n.a. n.a. n.a.
Finafloxacin 1–2 n.a. [22]
Zabofloxacin 0.008 ≥ 4 2 [24]
Nemonoxacin 0.12–8 4 [34]
E. faecium Avarofloxacin 0.25–4 4 [10]
Ciprofloxacin 1 ≥ 16 >16 [10]
Delafloxacin n.a. n.a. n.a.
Finafloxacin n.a. n.a. n.a.
Zabofloxacin 2–32 16 [24]
Nemonoxacin 0.06–16 16 [34]
E. coli Avarofloxacin 1–16 16 [10]
Ciprofloxacin 16 ≥ 256 256 [10]
Delafloxacin 2–128 n.a. [43]
Finafloxacin 16 ≥ 256 256 [41]
Zabofloxacin 0.015–64 1 [24]
Nemonoxacin 0.5–32 32 [31]
K. pneumoniae Avarofloxacin ≤0.015–1 0.25 [10]
Ciprofloxacin ≤0.004–1 0.25 [10]
Delafloxacin n.a. n.a. n.a.
Finafloxacin 0.015–0.6 n.a. [22]
Zabofloxacin 0.06–8 1 [24]
Nemonoxacin 0.5–32 2 [31]
P. aeruginosa Avarofloxacin 0.5–4 2 [10]
Ciprofloxacin 0.12–1 0.5 [10]
Delafloxacin 0.016–1 n.a. [43]
Finafloxacin 0.25–8 2 [41]
Zabofloxacin <0.008 ≥ 64 >64 [24]
Nemonoxacin 0.12–32 32 [31]
H. influenzae Avarofloxacin 0.008–0.015 0.015 [10]
Ciprofloxacin 0.008–0.015 0.015 [10]
Delafloxacin n.a. n.a. n.a.
Finafloxacin n.a. n.a. n.a.
Zabofloxacin <0.008–0.008 0.008 [24]
Nemonoxacin ≤0.008–0.06 n.a. [38]

All values are in mg/L

Ref reference number