Table 2.
Organism | Antibacterial agents | MIC range | MIC90 | Ref. |
---|---|---|---|---|
S. pneumoniae | Avarofloxacin | 0.06–0.5 | 0.25 | [10] |
ciprofloxacin | 8–64 | 64 | [10] | |
Delafloxacin | n.a. | n.a. | n.a. | |
Finafloxacin | 0.5–4 | 2 | [41] | |
Zabofloxacin | 0.015–0.06 | 0.03 | [24] | |
Nemonoxacin | 0.03–1 | 0.06 | [34] | |
S. aureus, MRSA FQ-resistant | Avarofloxacin | 0.015–2 | 0.25 | [10] |
Ciprofloxacin | 4 ≥ 256 | 64 | [10] | |
Delafloxacin | ≤0.004–0.12 | 0.06 | [15] | |
Finafloxacin | 0.25–32 | 4 | [41] | |
Zabofloxacin | 0.016–64 | 32 | [26] | |
Nemonoxacin | 0.5–1 | 1 | [34] | |
S. aureus, MRSA FQ-susceptible | Avarofloxacin | 0.008–0.015 | 0.008 | [42] |
Ciprofloxacin | 0.25–1 | 0.5 | [42] | |
Delafloxacin | 0.008–1 | 0.5 | [13] | |
Finafloxacin | 0.06–0.125 | 0.125 | [41] | |
Zabofloxacin | 0.016–1 | 0.125 | [26] | |
Nemonoxacin | ≤0.008–0.12 | 0.06 | [31] | |
E. faecalis | Avarofloxacin | 0.03–1 | 0.5 | [10] |
Ciprofloxacin | 0.5–>16 | >16 | [10] | |
Delafloxacin | n.a. | n.a. | n.a. | |
Finafloxacin | 1–2 | n.a. | [22] | |
Zabofloxacin | 0.008 ≥ 4 | 2 | [24] | |
Nemonoxacin | 0.12–8 | 4 | [34] | |
E. faecium | Avarofloxacin | 0.25–4 | 4 | [10] |
Ciprofloxacin | 1 ≥ 16 | >16 | [10] | |
Delafloxacin | n.a. | n.a. | n.a. | |
Finafloxacin | n.a. | n.a. | n.a. | |
Zabofloxacin | 2–32 | 16 | [24] | |
Nemonoxacin | 0.06–16 | 16 | [34] | |
E. coli | Avarofloxacin | 1–16 | 16 | [10] |
Ciprofloxacin | 16 ≥ 256 | 256 | [10] | |
Delafloxacin | 2–128 | n.a. | [43] | |
Finafloxacin | 16 ≥ 256 | 256 | [41] | |
Zabofloxacin | 0.015–64 | 1 | [24] | |
Nemonoxacin | 0.5–32 | 32 | [31] | |
K. pneumoniae | Avarofloxacin | ≤0.015–1 | 0.25 | [10] |
Ciprofloxacin | ≤0.004–1 | 0.25 | [10] | |
Delafloxacin | n.a. | n.a. | n.a. | |
Finafloxacin | 0.015–0.6 | n.a. | [22] | |
Zabofloxacin | 0.06–8 | 1 | [24] | |
Nemonoxacin | 0.5–32 | 2 | [31] | |
P. aeruginosa | Avarofloxacin | 0.5–4 | 2 | [10] |
Ciprofloxacin | 0.12–1 | 0.5 | [10] | |
Delafloxacin | 0.016–1 | n.a. | [43] | |
Finafloxacin | 0.25–8 | 2 | [41] | |
Zabofloxacin | <0.008 ≥ 64 | >64 | [24] | |
Nemonoxacin | 0.12–32 | 32 | [31] | |
H. influenzae | Avarofloxacin | 0.008–0.015 | 0.015 | [10] |
Ciprofloxacin | 0.008–0.015 | 0.015 | [10] | |
Delafloxacin | n.a. | n.a. | n.a. | |
Finafloxacin | n.a. | n.a. | n.a. | |
Zabofloxacin | <0.008–0.008 | 0.008 | [24] | |
Nemonoxacin | ≤0.008–0.06 | n.a. | [38] |
All values are in mg/L
Ref reference number